circRNA basic information
circBase ID: hsa_circ_0000378
Name: hsa_circ_LRP6
Synonym: circ_Lrp6 / circ_00468_LRP6
Host Gene: LRP6
Genomic location(hg19): chr12:12397195-12397589:-
Genomic location(hg38): chr12:12244261-12244655:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005115
MONDO name: temporal lobe epilepsy
Disease details: Temporal Lobe Epilepsy / TLE
Disease DO ID:
 3328
Disease MeSH ID:
 D004833
Disease NCIt ID:
 C177244
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

hippocampus; cortex; hippocampal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation
Clinical significance:

-
Description:

circ_Lrp6 is down-regulated in mTLE patient hippocampus compared with controls, supported by RNA-seq and RT-qPCR validation. The paper does not further characterize circ_Lrp6 mechanism or functional effects.
Confidence score:

0.5541
Other information
Title:

Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.

Journal: Frontiers in molecular neuroscience
Published: 2022
PubMed ID: 35310884
Study type:

combined biological and clinical study
Data availability: GSE186334
Code availability: -