| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
Potential biomarker candidate for aggressive TNBC; implicated in tumor proliferation and invasion-related programs via subtype-specific m6A regulation. |
| Molecular mechanism: |
Subtype-specific m6A hypermethylation; proposed to affect circRNA stability/translation and potentially ceRNA activity (not experimentally validated for this circRNA). |
| Biological pathway or process: |
Wnt/beta-catenin (other); proliferation (other); invasion (other); ceRNA regulation (other) |
| Detected method: |
M
|
| Validation methods: |
MeRIP / MeRIP-seq; Microarray; RNase R Treatment; Bioinformatics Analysis; ROC Analysis; Survival Analysis |
| Clinical significance: |
Excellent discriminatory power between TNBC and luminal tumors (AUC = 0.88); host gene ZBTB16 high expression associated with worse overall survival. |
| Description: |
hsa_circRNA_404935 (circZBTB16) is identified as a TNBC-associated circRNA with increased m6A methylation and reported upregulation versus luminal tumors, showing strong diagnostic discrimination (AUC ~0.88). The study links it to Wnt/beta-catenin-related enrichment and suggests prognostic relevance through the host gene ZBTB16 being associated with worse OS in TNBC. |
| Confidence score: |
0.6405 |