| Expression pattern: |
UP |
| Associated gene: |
CEACAM5 |
| Associated microRNA: |
hsa-miR-634, hsa-miR-944, hsa-miR-1207-5p, hsa-miR-143-3p, hsa-miR-146b-5p, hsa-miR-203a-3p, hsa-miR-216a-3p, hsa-miR-361-5p, hsa-miR-429 |
| Biological function: |
Potential biomarker for gastric cancer diagnosis and treatment. |
| Molecular mechanism: |
May act as a miRNA sponge and may regulate parental gene transcription. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
AUC=0.96 in distinguishing GC and normal patients (ROC analysis). |
| Description: |
circCEACAM5 is up-regulated in gastric cancer tissues versus adjacent normal tissues and was validated by RT-qPCR. Bioinformatic analyses suggest it may sponge GC-related miRNAs (including hsa-miR-429) and it shows high diagnostic performance by ROC analysis (AUC 0.96). |
| Confidence score: |
0.5963 |