| Expression pattern: |
UP |
| Associated gene: |
CHEK1, CDC25A, FOXK1 |
| Associated microRNA: |
hsa-miR-195-5p |
| Biological function: |
May contribute to LIHC onset and progression; the axis may be involved in facilitating immune escape in the LIHC microenvironment. |
| Molecular mechanism: |
ceRNA network: hsa_circ_0017264 sponges hsa-miR-195-5p to regulate CHEK1/CDC25A/FOXK1. |
| Biological pathway or process: |
ceRNA regulation (other); cell cycle (promotes); p53 signaling (promotes); Wnt/beta-catenin (promotes); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Clinical Sample Validation; divergent primers PCR; Sanger Sequencing; Survival Analysis |
| Clinical significance: |
Survival-related ceRNA network; may provide potential prognostic biomarkers and therapeutic targets for LIHC. |
| Description: |
hsa_circ_0017264 is up-regulated in LIHC tissues and is proposed to act in a ceRNA network by sequestering hsa-miR-195-5p, thereby affecting CHEK1/CDC25A/FOXK1. This axis is linked to cell-cycle and cancer-related pathways and is associated with immune infiltration/immune checkpoint correlations, suggesting a role in LIHC progression and immune escape. |
| Confidence score: |
0.6556 |