| Expression pattern: |
UP |
| Associated gene: |
USP3 |
| Associated microRNA: |
miR-224-5p |
| Biological function: |
Promotes gastric cancer cell proliferation, migration, tumor growth and metastasis; downregulation suppresses these malignant phenotypes. |
| Molecular mechanism: |
hsa_circ_0017639 functions as a ceRNA by sponging miR-224-5p and regulating the miR-224-5p/USP3 axis, thereby upregulating USP3. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Bioinformatics Analysis; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
Potential effective therapeutic target for gastric cancer. |
| Description: |
hsa_circ_0017639 is upregulated in gastric cancer cell lines and mainly localized in the cytoplasm. It promotes gastric cancer proliferation, migration and xenograft tumor growth by sponging miR-224-5p and regulating USP3 through the miR-224-5p/USP3 axis, suggesting potential therapeutic relevance. |
| Confidence score: |
0.657 |