| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-194 |
| Biological function: |
Promotes proliferation, migration, invasion and EMT in PTC cells. |
| Molecular mechanism: |
Acts as a ceRNA by directly binding miR-194 to relieve repression of ZEB1, thereby promoting EMT and malignant behaviors in PTC. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Transwell Assay; Western Blot; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
High intratumoral circVANGL1 expression was correlated with lymph node metastasis and advanced TNM stage (adverse clinical parameters). |
| Description: |
circVANGL1 is up-regulated in papillary thyroid cancer and promotes proliferation, migration, invasion and EMT. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-194 to de-repress ZEB1, contributing to PTC progression. |
| Confidence score: |
0.6777 |