| Expression pattern: |
UP |
| Associated gene: |
CCND1 |
| Associated microRNA: |
miR-142-5p |
| Biological function: |
Inhibits chondrocyte autophagy and promotes chondrocyte proliferation; its depletion induces apoptosis, reduces cartilage degeneration and increases ECM markers (collagen II, aggrecan) in OA models. |
| Molecular mechanism: |
ceRNA mechanism: circRHOT1 sponges miR-142-5p to enhance CCND1 expression, affecting chondrocyte proliferation/apoptosis and autophagy markers (LC3, beclin1). |
| Biological pathway or process: |
autophagy (inhibits); proliferation (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; TUNEL; Western Blot; In Vivo Animal Model; ELISA |
| Clinical significance: |
- |
| Description: |
circRHOT1 is up-regulated in osteoarthritis cartilage and promotes OA-associated chondrocyte proliferation while suppressing autophagy. It functions as a ceRNA by sponging miR-142-5p to increase CCND1 expression; circRHOT1 knockdown reverses OA phenotypes in rat ACLT model and in chondrocytes. |
| Confidence score: |
0.6545 |