| Expression pattern: |
UP |
| Associated gene: |
IGF2, IGF1R, GLS, BCL2, VEGFA, PI3K-Akt signaling |
| Associated microRNA: |
miR-153-3p, miR-490-5p, miR-615-3p, miR-503-5p |
| Biological function: |
promotes proliferation; inhibits apoptosis; promotes tumor growth in vivo; promotes glutaminolysis |
| Molecular mechanism: |
ceRNA mechanism: circHMGCS1 sponges miR-503-5p to upregulate IGF2/IGF1R, activating PI3K-Akt signaling and regulating GLS-driven glutaminolysis |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); PI3K/AKT (promotes); glutaminolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
H
S
|
| Validation methods: |
RNA-seq; RT-qPCR; ISH (In Situ Hybridization); Nuclear-Cytoplasmic Fractionation; Transfection; Luciferase Reporter Assay; Western Blot; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Bioinformatics Analysis; ROC Analysis; Survival Analysis |
| Clinical significance: |
High circHMGCS1 expression is associated with poor prognosis and shows diagnostic value in distinguishing HB tissues from normal tissues. |
| Description: |
circHMGCS1 (hsa_circ_0072391) is up-regulated in hepatoblastoma tissues/cells and mainly localized in the cytoplasm. It promotes HB proliferation, survival, tumor growth and glutaminolysis by sponging miR-503-5p to increase IGF2/IGF1R and activate PI3K/AKT signaling, and high circHMGCS1 predicts poorer overall survival with diagnostic potential. |
| Confidence score: |
0.7533 |