| Expression pattern: |
UP |
| Associated gene: |
MAPK9 |
| Associated microRNA: |
- |
| Biological function: |
CircRNA_0001566 is highly expressed in RA PBMCs, shows diagnostic biomarker potential, and is predicted to promote T-cell activation through the PI3K-Akt signaling pathway; its associated miRNAs are enriched in cell proliferation and cell cycle regulation processes. |
| Molecular mechanism: |
Predicted ceRNA mechanism involving sponging target miRNAs and promoting T-cell activation through the PI3K-Akt signaling pathway. |
| Biological pathway or process: |
PI3K/AKT (promotes); immune regulation (promotes); proliferation (promotes); cell cycle (other); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
CircRNA_0001566 is a promising diagnostic biomarker for RA; AUC = 0.751 (95%CI 0.673, 0.830) in ROC analysis. It showed no significant correlation with ESR or CRP. |
| Description: |
CircRNA_0001566 was identified as significantly upregulated in PBMCs from RA patients and validated by RT-qPCR in a clinical cohort. It showed diagnostic biomarker potential for RA, while bioinformatics analyses predicted that it may contribute to RA pathogenesis through miRNA-related regulation of PI3K-Akt-mediated T-cell activation and processes related to cell proliferation and cell cycle regulation. |
| Confidence score: |
0.559 |