circRNA basic information
circBase ID: hsa_circ_0012152
Name: hsa_circ_RNF220
Synonym: circRNF220
Host Gene: RNF220
Genomic location(hg19): chr1:44877652-44878394:+
Genomic location(hg38): chr1:44411980-44412722:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia / AML
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow; CD34+ cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: PVR
Associated microRNA: miR-92a-1-5p
Biological function: associated with immune evasion during AML relapse after transplantation
Molecular mechanism: acts as a miRNA sponge (ceRNA) for miR-92a-1-5p to upregulate PVR
Biological pathway or process:

immune regulation (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

potential biomarker for post-transplant relapse
Description:

Hsa_circ_0012152 (circRNF220) is up-regulated in relapsed AML blasts after allo-HSCT and is implicated in immune evasion. It may function as a ceRNA by sponging miR-92a-1-5p to increase PVR expression.
Confidence score:

0.4032
Other information
Title:

Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

Journal: Genes
Published: 2022
PubMed ID: 36360223
Study type:

combined biological and clinical study
Data availability: The raw data supporting the conclusion of the present article will be made available by the author.
Code availability: -