circRNA basic information
circBase ID: -
Name: hsa_circ_RPPH1
Synonym: circ_RPPH1
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; para-carcinoma tissues; tumor tissues
Cell lines:

MCF-7; MDA-MB-231
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TRIM14
Associated microRNA: miR-1296-5p
Biological function: promotes proliferation, migration and invasion; alters cell cycle; inhibits apoptosis; promotes tumor growth in vivo
Molecular mechanism: ceRNA mechanism: circ_RPPH1 directly binds (sponges) miR-1296-5p to up-regulate TRIM14
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); cell cycle (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

circ_RPPH1 is highly expressed in BC tissues and suggested as a potential biomarker and therapeutic target
Description:

circ_RPPH1 is up-regulated in breast cancer tissues and promotes malignant behaviors (proliferation, migration, invasion), shifts the cell cycle toward S phase, and inhibits apoptosis. Mechanistically, it functions as a ceRNA by binding miR-1296-5p to de-repress TRIM14, enhancing tumor growth in a xenograft model.
Confidence score:

0.7133
Other information
Title:

Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis.

Journal: Cancer biology & therapy
Published: 2024
PubMed ID: 38816350
Study type:

combined biological and clinical study
Data availability: available upon reasonable request from the corresponding author; https://doi.org/10.1080/15384047.2024.2360768
Code availability: -