| Expression pattern: |
DN |
| Associated gene: |
ELAVL1, SMAD7 |
| Associated microRNA: |
miR-513c-5p |
| Biological function: |
promotes proliferation; inhibits apoptosis in hypoxia-induced cardiomyocytes |
| Molecular mechanism: |
recruits ELAVL1 to stabilize SMAD7 mRNA (RBP-mediated mRNA stability regulation), not via ceRNA with miR-513c-5p |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); mRNA stability (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Western Blot; IF (Immunofluorescence); Bioinformatics Analysis |
| Clinical significance: |
might function as a novel biomarker in cells under hypoxia |
| Description: |
hsa_circ_0000848 is down-regulated in hypoxia-induced cardiomyocytes. Its knockdown suppresses proliferation and increases apoptosis. Mechanistically, it binds the RBP ELAVL1 to enhance SMAD7 mRNA stability and SMAD7 expression, and SMAD7 overexpression rescues the effects of hsa_circ_0000848 silencing. |
| Confidence score: |
0.7909 |