| Expression pattern: |
UP |
| Associated gene: |
ELK1, ARHGAP26 |
| Associated microRNA: |
miR-330-5p |
| Biological function: |
circ_0074371 promotes LPS-induced HK2 cell injury, including reduced cell viability, apoptosis, inflammatory response and oxidative stress; knockdown of circ_0074371 ameliorates these injury phenotypes. |
| Molecular mechanism: |
circ_0074371 functions as a sponge for miR-330-5p and increases ELK1 expression, forming a circ_0074371/miR-330-5p/ELK1 regulatory axis in LPS-induced HK2 cell injury. |
| Biological pathway or process: |
apoptosis (promotes); proliferation (inhibits); inflammation (promotes); ceRNA regulation (other); other pathway/process (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNase R Treatment; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; ELISA; Western Blot |
| Clinical significance: |
circ_0074371 was upregulated in septic AKI patient serum and may provide a new therapeutic target for sepsis-related AKI. |
| Description: |
circ_0074371 is up-regulated in septic AKI patient serum and LPS-induced HK2 cells. Its knockdown alleviates LPS-induced HK2 cell injury by improving viability and suppressing apoptosis, inflammation and oxidative stress. Mechanistically, circ_0074371 sponges miR-330-5p to increase ELK1 expression, forming a circ_0074371/miR-330-5p/ELK1 axis. |
| Confidence score: |
0.7404 |