circRNA basic information
circBase ID: -
Name: -
Synonym: hsa_circRNA_101969
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissue; adjacent normal tissue; fresh frozen tissue; formalin-fixed paraffin-embedded tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Differentially expressed in lung adenocarcinoma and proposed as a potential lung adenocarcinoma-related circRNA/biomarker candidate; no functional cell phenotype assay was reported.
Molecular mechanism: Predicted circRNA-miRNA-protein coding gene interaction network.
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

Potential lung adenocarcinoma-related circRNA and potential biomarker candidate; FFPE specimens may be used for circRNA biomarker discovery.
Description:

hsa_circRNA_101969 was down-regulated in lung adenocarcinoma tissues and its expression pattern was confirmed by qRT-PCR. The study also constructed a predicted circRNA-miRNA-mRNA regulatory network for this circRNA, supporting its role as a potential lung adenocarcinoma-related circRNA candidate.
Confidence score:

0.5135
Other information
Title:

circRNA expression analysis in lung adenocarcinoma: comparison of paired fresh frozen and formalin-fixed paraffin-embedded specimens.

Journal: Biochemical and biophysical research communications
Published: 2018
PubMed ID: 29679573
Study type:

combined clinical and bioinformatics study
Data availability: Supplementary file 1; Supplementary file 2; Supplementary file 3; Supplementary file 4; Supplementary File 5; https://doi.org/10.1016/j.bbrc.2018.04.145
Code availability: -