circRNA basic information
circBase ID: hsa_circ_0000885
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr19:7267355-7267907:-
Genomic location(hg38): chr19:7267344-7267896:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

osteosarcoma tissues; adjacent normal tissue; serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: -
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

circRNA-seq; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Cohort Study
Clinical significance:

High serum and tumor levels of hsa_circ_0000885 were associated with lower disease-free survival and overall survival, and serum hsa_circ_0000885 could distinguish osteosarcoma from healthy controls and benign bone tumors (diagnostic biomarker).
Description:

hsa_circ_0000885 is upregulated in osteosarcoma tissues and patient serum, correlates with advanced stage and lung metastasis, and is associated with worse disease-free and overall survival. It may serve as a diagnostic biomarker (serum) and a prognostic biomarker for osteosarcoma.
Confidence score:

0.6518
Other information
Title:

Circular RNA hsa_circ_0000885 Levels are Increased in Tissue and Serum Samples from Patients with Osteosarcoma.

Journal: Medical science monitor : international medical journal of experimental and clinical research
Published: 2019
PubMed ID: 30802235
Study type:

combined biological and clinical study
Data availability: -
Code availability: -