| Expression pattern: |
UP |
| Associated gene: |
EIF4G2 |
| Associated microRNA: |
miR-146a-5p |
| Biological function: |
Promotes NSCLC cell proliferation, migration and invasion; inhibits apoptosis; promotes tumor growth in vivo; contributes to angiogenesis and cisplatin (DDP) drug resistance. |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-146a-5p to upregulate EIF4G2 expression. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); angiogenesis (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_0020123 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-146a-5p to relieve repression of EIF4G2, and its knockdown suppresses tumor growth in a xenograft model. |
| Confidence score: |
0.7797 |