circRNA basic information
circBase ID: hsa_circ_0072309
Name: hsa_circ_LIFR
Synonym: -
Host Gene: LIFR
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum; LAC tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Potentially interferes with NSCLC progression (associated with lymph node metastasis and advanced stage).
Molecular mechanism: Not explored in depth in this study.
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study; Bioinformatics Analysis
Clinical significance:

Low expression is associated with lymph node metastasis, advanced TNM stage, and adverse 3-year survival; diagnostic biomarker with AUC 0.887 and improved performance when combined with CEA or CYFRA21-1.
Description:

hsa_circ_0072309 (LIFR) is down-regulated in NSCLC and is associated with lymph node metastasis, advanced stage, and poorer survival when expressed at low levels. It also shows diagnostic value (AUC 0.887), with improved performance when combined with CEA or CYFRA21-1; the mechanism was not deeply explored.
Confidence score:

0.5734
Other information
Title:

hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis.

Journal: Frontiers in surgery
Published: 2022
PubMed ID: 35284481
Study type:

combined biological and clinical study
Data availability: GSE101684; GSE112214
Code availability: -