| Expression pattern: |
DN |
| Associated gene: |
LRPPRC, LATS2, YAP |
| Associated microRNA: |
miR-107 |
| Biological function: |
Inhibits proliferation, migration and invasion; promotes apoptosis; suppresses tumor growth in vivo. |
| Molecular mechanism: |
Binds LRPPRC to inhibit its activity, reducing mitochondrial mRNA levels and mitochondria abundance; acts as a miR-107 sponge to upregulate LATS2, increasing phosphorylated YAP and inhibiting YAP activity. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); Hippo/YAP (inhibits); mitochondrial function (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; Luciferase Reporter Assay; RNA-seq; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; In Vivo Animal Model; IHC (Immunohistochemistry); H&E Staining; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
Good diagnostic utility in OC tissues; expression negatively correlated with FIGO stages, grades, peritoneal implantation, and CA125 levels; potential prognostic biomarker and therapeutic target. |
| Description: |
hsa_circ_0020093 is down-regulated in ovarian cancer and acts as a tumor suppressor. It binds the mitochondrial protein LRPPRC to reduce mitochondrial mRNA levels/mitochondria abundance, and sponges miR-107 to upregulate LATS2, leading to increased YAP phosphorylation and reduced YAP activity, thereby inhibiting malignant behaviors and tumor growth. |
| Confidence score: |
0.8073 |