| Expression pattern: |
UP |
| Associated gene: |
ZNF83 |
| Associated microRNA: |
miR-125a-5p |
| Biological function: |
Promotes breast cancer cell migration and invasion; knockdown suppresses cell migration and invasion. |
| Molecular mechanism: |
hsa_circ_0052112 acts as a sponge for miR-125a-5p and may promote migration and invasion through up-regulating ZNF83 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); migration (promotes); invasion (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Microarray; FISH / smFISH; Luciferase Reporter Assay; Transfection; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0052112 may serve as a novel biomarker and provide a potent therapeutic target of breast cancer. |
| Description: |
hsa_circ_0052112 is a ZNF83-derived circRNA upregulated in the highly invasive breast cancer cell line MDA-MB-231 compared with MCF-7. It promotes breast cancer cell migration and invasion by sponging miR-125a-5p, and may also increase ZNF83 expression. The authors propose hsa_circ_0052112 as a potential biomarker and therapeutic target for breast cancer. |
| Confidence score: |
0.7006 |