circRNA basic information
circBase ID: mmu_circ_0001052
Name: mmu_circ_HIPK3
Synonym: -
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002771
MONDO name: pulmonary fibrosis
Disease details: pulmonary fibrosis
Disease DO ID:
 3770
Disease MeSH ID:
 D011658
Disease NCIt ID:
 C26869
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

lung
Cell lines:

-
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: SOX4, COL1A1
Associated microRNA: miR-338-3p
Biological function: Promotes bleomycin-induced pulmonary fibrosis; circHIPK3 knockdown reduces collagen deposition and myofibroblast markers in vivo.
Molecular mechanism: In vivo evidence supports circHIPK3 as a profibrotic regulator; knockdown decreases SOX4 and COL1A1 expression in bleomycin-induced fibrosis lungs.
Biological pathway or process:

fibrosis (promotes); proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RNase R Treatment; RT-qPCR; Sanger Sequencing; divergent primers PCR; Transfection; Western Blot; IF (Immunofluorescence); In Vivo Animal Model; H&E Staining
Clinical significance:

-
Description:

Mouse circHIPK3 (mmu_circ_0001052) is up-regulated in bleomycin-induced pulmonary fibrosis lungs. In vivo knockdown reduces fibrotic collagen deposition and lowers SOX4/COL1A1 expression, supporting a profibrotic role.
Confidence score:

0.6306
Other information
Title:

circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.

Journal: Cell death & disease
Published: 2019
PubMed ID: 30796204
Study type:

biological research
Data availability: Supplementary Information accompanies this paper at (10.1038/s41419-019-1430-7).
Code availability: -