| Expression pattern: |
UP |
| Associated gene: |
CCND1, N-cadherin, PD-L1, TNF-alpha, IFN-gamma |
| Associated microRNA: |
miR-193a-3p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion, EMT-related changes, and potential immune evasion; inhibits apoptosis through the miR-193a-3p/CCND1 axis. |
| Molecular mechanism: |
Hsa_circ_0002103 acts as a molecular sponge for miR-193a-3p, alleviating miR-193a-3p-mediated repression of CCND1 and positively regulating CCND1 expression. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); immune regulation (promotes); immune regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Clinical Sample Validation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; ELISA; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
May serve as a potential therapeutic target and biomarker for CRC; extracellular hsa_circ_0002103 is nominated as a candidate for non-invasive liquid biopsy development. |
| Description: |
Hsa_circ_0002103 is upregulated in CRC cell lines and patient plasma. It promotes CRC progression by sponging miR-193a-3p to increase CCND1 expression, thereby facilitating proliferation, migration, invasion, EMT-related changes, and potential immune evasion while suppressing apoptosis. The study suggests hsa_circ_0002103 may be a therapeutic target and biomarker for CRC. |
| Confidence score: |
0.7519 |