| Expression pattern: |
UP |
| Associated gene: |
IMP3, EGF, ID1, ID3, AKT1, VEGFA, SIRT1 |
| Associated microRNA: |
hsa let7a-5p, MiR-143-3p |
| Biological function: |
promotes cell proliferation, migration, invasion, and oxidative phosphorylation/bioenergetics in breast and ovarian cancer cells |
| Molecular mechanism: |
Loss- and gain-of-function perturbation alters transcriptome and mitochondrial respiration; predicted association with Let-7 family miRNAs and multiple RBPs (database/CLIP-supported). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); oxidative phosphorylation (promotes); mitochondrial function (promotes); glycolysis (promotes); NF-kappaB (other); PI3K/AKT (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RT-qPCR; RNA-seq; divergent primers PCR; Sanger Sequencing; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Transfection; MTT; Wound Healing Assay; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
In breast and ovarian cancer cell lines, circNFATC3 promotes proliferative and motile phenotypes and supports mitochondrial respiration/oxidative phosphorylation. siRNA knockdown reduces proliferation, migration/invasion and lowers OCR/ECAR, while circRNA mini-vector overexpression increases these phenotypes. The circRNA is mainly cytoplasmic and is predicted (database-based) to interact with Let-7 family miRNAs and multiple RBPs. |
| Confidence score: |
0.6956 |