circRNA basic information
circBase ID: hsa_circ_0052011
Name: hsa_circ_POLD1
Synonym: -
Host Gene: POLD1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0043905
MONDO name: pneumonitis
Disease details: PS-NPs-induced DNA damage in the lung
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 C113159
Disease ICD11 ID:
 1324545867
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human bronchoalveolar lavage fluid (BALF); lung tissues; mouse lung tissue
Cell lines:

16HBE
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: FEN1
Associated microRNA: -
Biological function: CircRNA0052011 alleviates PS-NPs-induced DNA damage, preserves FEN1 stability, promotes DNA repair, and mitigates nanoplastics-induced genotoxic stress.
Molecular mechanism: CircRNA0052011 directly interacts with FEN1 and stabilizes FEN1 protein by decreasing FEN1 ubiquitination, thereby enhancing FEN1-mediated DNA damage repair in response to PS-NPs-induced genotoxic stress.
Biological pathway or process:

other pathway/process (promotes); mRNA stability (other); ubiquitination (inhibits)
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

circRNA0052011 was suggested as a potential biomarker and therapeutic target for environmental pollutant-related diseases.
Description:

circRNA0052011 is downregulated after PS-NPs exposure in bronchial epithelial cells and mouse lung. It acts as a protective circRNA by directly binding FEN1, reducing FEN1 ubiquitination, stabilizing FEN1 protein, and promoting DNA repair to mitigate PS-NPs-induced genotoxicity and lung injury.
Confidence score:

0.8335
Other information
Title:

CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung.

Journal: Environment international
Published: 2026
PubMed ID: 41904925
Study type:

combined biological and clinical study
Data availability: Data will be made available on request; Supplementary Table S4; Supplementary data to this article can be found online at https://doi. org/10.1016/j.envint.2026.110211.
Code availability: -