circRNA basic information
circBase ID: hsa_circ_0025042
Name: hsa_circ_FOXM1
Synonym: circFOXM1
Host Gene: FOXM1
Genomic location(hg19): chr12:2983142-2983691:-
Genomic location(hg38): chr12:2873976-2874525:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0015459
MONDO name: nasopharyngeal carcinoma
Disease details: nasopharyngeal carcinoma / NPC
Disease DO ID:
 9261
Disease MeSH ID:
 D00007727; D000077274
Disease NCIt ID:
 C3871
Disease ICD11 ID:
 1883313543
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

frozen NPC tissues; normal nasopharyngeal epithelial tissues
Cell lines:

SUNE1; CNE1; HNE1; CNE2; 5-8F; 6-10B; C666; NP69
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: SMAD2
Associated microRNA: miR-136-5p
Biological function: promotes proliferation, migration, invasion and EMT of nasopharyngeal carcinoma cells
Molecular mechanism: ceRNA mechanism: circFOXM1 sponges miR-136-5p to upregulate SMAD2 and promote EMT
Biological pathway or process:

EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis
Clinical significance:

High expression of circFOXM1 indicates a poor prognosis for nasopharyngeal carcinoma; circFOXM1 expression is related to clinical stage
Description:

circFOXM1 is up-regulated in nasopharyngeal carcinoma and mainly localized in the cytoplasm. It promotes NPC cell proliferation, migration, invasion and EMT by acting as a ceRNA that sponges miR-136-5p to increase SMAD2 expression. High circFOXM1 expression is associated with advanced stage and poor prognosis.
Confidence score:

0.8396
Other information
Title:

CircFOXM1 acts as a ceRNA to upregulate SMAD2 and promote the progression of nasopharyngeal carcinoma.

Journal: Molecular genetics & genomic medicine
Published: 2022
PubMed ID: 35266323
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -