circRNA basic information
circBase ID: hsa_circ_0001831
Name: hsa_circ_SCRIB
Synonym: -
Host Gene: SCRIB
Genomic location(hg19): chr8:144894444-144895014:+
Genomic location(hg38): chr8:143812274-143812844:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005016
MONDO name: diabetic kidney disease
Disease details: diabetic nephropathy / DN
Disease DO ID:
 -
Disease MeSH ID:
 D003928
Disease NCIt ID:
 C84417
Disease ICD11 ID:
 615062102
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-3151-5p, hsa-miR-6791-5p, hsa-miR-939-5p, hsa-miR-637, hsa-miR-7974
Biological function: Potential diagnostic biomarker for ET2DN
Molecular mechanism: Predicted circRNA-microRNA-mRNA interaction network (ceRNA-like); mechanism not experimentally validated
Biological pathway or process:

ceRNA regulation (other); not specified
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC curve analysis showed high diagnostic value for ET2DN (AUC 0.95; sensitivity 0.85; specificity 0.85).
Description:

hsa_circ_0001831 is significantly up-regulated in peripheral blood of ET2DN patients versus T2DM and controls and shows strong diagnostic performance by ROC analysis. The study predicts a circRNA-miRNA-mRNA interaction network (including hsa-miR-3151-5p, hsa-miR-6791-5p, hsa-miR-939-5p, hsa-miR-637, hsa-miR-7974) but does not experimentally validate downstream targets.
Confidence score:

0.5963
Other information
Title:

Peripheral Blood circRNA Microarray Profiling Identities hsa_circ_0001831 and hsa_circ_0000867 as Two Novel circRNA Biomarkers for Early Type 2 Diabetic Nephropathy.

Journal: Diabetes, metabolic syndrome and obesity : targets and therapy
Published: 2022
PubMed ID: 36118796
Study type:

combined biological and clinical study
Data availability: -
Code availability: -