circRNA basic information
circBase ID: hsa_circ_0043256
Name: hsa_circ_ACACA
Synonym: hsa_-circ_0043256
Host Gene: ACACA
Genomic location(hg19): chr17:35604934-35609962:-
Genomic location(hg38): chr17:37248010-37253036:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

human NSCLC tumor tissues and adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Diagnostic biomarker candidate; down-regulated in NSCLC
Molecular mechanism: Bioinformatics prediction and circRNA-miRNA network analysis
Biological pathway or process:

apoptosis (promotes); ceRNA regulation (other); ubiquitination (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis; ROC Analysis
Clinical significance:

could distinguish NSCLC patients from healthy individuals in GSE101586, GSEE101684, GSE112214 datasets
Description:

hsa_circ_0043256 was identified as a differentially expressed circRNA in NSCLC and was significantly down-regulated compared with controls. The discussion also cites prior work suggesting a circ_0043256/miR-1252/ITCH axis that promotes apoptosis, and the circRNA showed diagnostic potential in public datasets.
Confidence score:

0.348
Other information
Title:

Identification of Key circRNAs in Non-Small Cell Lung Cancer.

Journal: The American journal of the medical sciences
Published: 2021
PubMed ID: 32962802
Study type:

bioinformatics study
Data availability: GSE101586; GSEE101684; GSE112214
Code availability: -