| Expression pattern: |
UP |
| Associated gene: |
CD80 |
| Associated microRNA: |
miR-455-3p / hsa-miR-455-3p |
| Biological function: |
promotes cell growth; promotes migration and invasion; inhibits apoptosis; promotes inflammatory factors expression; promotes tumor growth in vivo |
| Molecular mechanism: |
ceRNA mechanism: circ_102049 sponges miR-455-3p to upregulate CD80 |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); invasion (promotes); inflammation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
might be selected as a promising prognostic marker and therapeutic target for PDAC |
| Description: |
In PDAC, circ_102049 (circTADA2A; hsa_circRNA_102049/hsa_circ_0043278) is up-regulated and mainly cytoplasmic. It promotes proliferation, migration/invasion and inflammatory factor expression while inhibiting apoptosis, partly by sponging miR-455-3p to upregulate CD80, and its knockdown suppresses tumor growth in a cell line-derived xenograft model. |
| Confidence score: |
0.7346 |