circRNA basic information
circBase ID: -
Name: hsa_circ_MTCL1
Synonym: hsa_circRNA_102293
Host Gene: MTCL1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tumor tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: miR-30b-5p, miR-30e-5p
Biological function: Potential diagnostic biomarker for CRC (high diagnostic efficiency by ROC); suggested involvement in CRC pathogenesis.
Molecular mechanism: Predicted ceRNA network (cirReNET); predicted binding to miR-30 family members (miR-30b-5p, miR-30e-5p) (bioinformatics prediction).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Diagnostic marker for CRC (ROC AUC = 0.9486).
Description:

hsa_circRNA_102293 (host gene MTCL1) is significantly down-regulated in CRC tissues and has diagnostic value (AUC 0.9486). The study predicts it may sponge miR-30 family members (miR-30b-5p and miR-30e-5p) within a circRNA-miRNA-mRNA ceRNA network, but does not experimentally validate this mechanism.
Confidence score:

0.5963
Other information
Title:

Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.

Journal: PeerJ
Published: 2022
PubMed ID: 35611168
Study type:

combined biological and clinical study
Data availability: GSE197991; Supplemental File
Code availability: -