circRNA basic information
circBase ID: hsa_circ_0052184
Name: hsa_circ_PPP1R12C
Synonym: -
Host Gene: PPP1R12C
Genomic location(hg19): chr19:55603809-55604030:-
Genomic location(hg38): chr19:55092441-55092662:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; CRC tissues; adjacent healthy tissues
Cell lines:

HCT116; HT29; SW480; SW620; NCM460
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Promotes CRC cell proliferation, migration and invasion; its deficiency inhibits proliferation and metastasis-related behaviors.
Molecular mechanism: Not further investigated in this study.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
S
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis; Cohort Study; Survival Analysis; Transfection; CCK8; Transwell Assay; Bioinformatics Analysis; RNA-seq
Clinical significance:

Elevated circulating/plasma hsa_circ_0052184 is associated with advanced disease stage and worse outcome; it is a stand-alone predictor of poor prognosis and shows diagnostic value (AUC 0.9072).
Description:

hsa_circ_0052184 is up-regulated in CRC tissues, CRC cell lines, and patient plasma. Functional knockdown in CRC cells suppresses proliferation, migration, and invasion, and clinically higher plasma levels are linked to worse survival and show high diagnostic performance.
Confidence score:

0.7085
Other information
Title:

Exploration into Plasma Hsa_circ_0052184 as a New Biomarker of Colorectal Cancer Prognosis.

Journal: Pharmacogenomics and personalized medicine
Published: 2023
PubMed ID: 37333495
Study type:

combined biological and clinical study
Data availability: GSE172229
Code availability: -