circRNA basic information
circBase ID: hsa_circ_0043278
Name: hsa_circ_TADA2A
Synonym: -
Host Gene: TADA2A
Genomic location(hg19): chr17:35797838-35800763:+
Genomic location(hg38): chr17:37437737-37440662:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer tissues; normal mammary gland tissues
Cell lines:

MCF-10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Survival Analysis; Cohort Study
Clinical significance:

circTADA2A-E5/E6 had diagnostic value in TNBC by ROC analysis (AUC 0.9366). Low circTADA2A-E5/E6 levels were associated with shorter DFS and OS, but not statistically significant; no significant correlation between DFS/OS and circTADA2A-E5/E6 expression.
Description:

circTADA2A-E5/E6 (hsa_circ_0043278) is down-regulated in breast cancer/TNBC and was validated by RT-qPCR in clinical specimens and cell lines. It shows high diagnostic performance in TNBC by ROC analysis, but its association with survival and clinicopathologic parameters was not significant in this study, and no functional/mechanistic experiments were reported for this circRNA.
Confidence score:

0.5416
Other information
Title:

circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.

Journal: Cell death & disease
Published: 2019
PubMed ID: 30787278
Study type:

combined biological and clinical study
Data availability: GSE101124
Code availability: -