| Expression pattern: |
UP |
| Associated gene: |
CEA, CA199 |
| Associated microRNA: |
- |
| Biological function: |
auxiliary diagnostic biomarker for gastric cancer; associated with tumor differentiation, tumor invasion depth, and lymph node metastasis; decreases after surgical resection |
| Molecular mechanism: |
- |
| Biological pathway or process: |
not specified |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RNase R Treatment; Actinomycin D / DRB Stability Assay; RT-qPCR; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; Clinical Sample Validation; ROC Analysis |
| Clinical significance: |
Plasma circ_0004592 differentiates GC patients from healthy donors (AUC 0.787) and decreases after surgery; high levels associate with histological classification, depth of tumor invasion, and lymph node metastasis. |
| Description: |
circ_0004592 (hsa_circ_0004592, from STK3) is up-regulated in gastric cancer tissues and patient plasma, including in precancerous lesions compared with healthy controls. Plasma levels decrease after tumor resection and show diagnostic value (ROC AUC ~0.787), with higher levels associated with invasion depth and lymph node metastasis. |
| Confidence score: |
0.6481 |