circRNA basic information
circBase ID: hsa_circ_0072309
Name: hsa_circ_LIFR
Synonym: circLIFR
Host Gene: LIFR
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005070
MONDO name: neoplasm
Disease details: neoplasm
Disease DO ID:
 14566
Disease MeSH ID:
 D009369
Disease NCIt ID:
 C3262
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissues
Cell lines:

KYSE30; KYSE150; SK-Hep-1; HCT-116
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: inhibits cell migration and tumor metastasis
Molecular mechanism: circLIFR regulates expression of cell adhesion and EMT-related genes (mechanism in ESCC unclear/not fully defined in this study)
Biological pathway or process:

migration (inhibits); metastasis (inhibits); EMT (inhibits)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Actinomycin D / DRB Stability Assay; Transfection; Transwell Assay; Wound Healing Assay; In Vivo Animal Model; H&E Staining; Bioinformatics Analysis
Clinical significance:

-
Description:

circLIFR (hsa_circ_0072309), derived from LIFR, is down-regulated in six solid tumors (LUAD, ESCC, CRC, GC, HCC, THCA). Functional assays show circLIFR suppresses cancer cell migration in vitro and metastasis in vivo, and transcriptome analyses suggest it modulates cell adhesion and EMT-related gene programs.
Confidence score:

0.7159
Other information
Title:

Characterization of distinct circular RNA signatures in solid tumors.

Journal: Molecular cancer
Published: 2022
PubMed ID: 35236349
Study type:

combined biological and clinical study
Data availability: 10.1186/s12943-022-01546-4; GSE98210
Code availability: -