circRNA basic information
circBase ID: hsa_circ_0000116
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr1:117944807-117948267:+
Genomic location(hg38): chr1:117402185-117405645:+
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma exosomes
Cell lines:

HOS; MG-63
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Facilitates OS cell malignancy by promoting proliferation, migration, and invasion.
Molecular mechanism: Exosomal hsa_circ_0000116 activates the PI3K/Akt/mTOR and p38/MAPK pathways.
Biological pathway or process:

PI3K/AKT/mTOR (promotes); MAPK (promotes); proliferation (promotes); migration (promotes); invasion (promotes)
Detected method:
Q
M
Validation methods:

RT-qPCR; Microarray; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot
Clinical significance:

-
Description:

This study identifies exosome-delivered hsa_circ_0000116 as an up-regulated circRNA in osteosarcoma-derived exosomes. Functional knockdown experiments indicate that hsa_circ_0000116 promotes OS cell proliferation, migration, and invasion, at least partly by activating PI3K/Akt/mTOR and p38/MAPK pathways.
Confidence score:

0.5067
Other information
Title:

Exosome-Delivered Hsa_Circ_0000116 Facilitates Osteosarcoma Cell Malignancy via PI3K/Akt/mTOR and p38/MAPK Pathways.

Journal: DNA and cell biology
Published: 2025
PubMed ID: 39778893
Study type:

biological and bioinformatics study
Data availability: GSE218526
Code availability: -