circRNA basic information
circBase ID: hsa_circ_0008813
Name: hsa_circ_UBA2
Synonym: hsa_circRNA_102532
Host Gene: UBA2
Genomic location(hg19): chr19:34942885-34955036:+
Genomic location(hg38): chr19:34451980-34464131:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005306
MONDO name: ankylosing spondylitis
Disease details: ankylosing spondylitis
Disease DO ID:
 7147
Disease MeSH ID:
 D013167
Disease NCIt ID:
 C84564
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

peripheral blood mononuclear cells (PBMCs); peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-658, hsa-miR-215-3p, hsa-miR-432-5p, hsa-miR-92a-1-5p, hsa-miR-144-5p
Biological function: Potential molecular marker for AS diagnosis.
Molecular mechanism: Acts as a miRNA sponge (predicted).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

ROC curve analysis showed that hsa_circRNA_102532 was statistically significant for distinguishing AS from HC (AUC ~0.642).
Description:

hsa_circRNA_102532 (hsa_circ_0008813; host gene UBA2) is up-regulated in PBMCs from AS patients, has predicted miRNA-sponging interactions, and shows modest diagnostic potential by ROC analysis.
Confidence score:

0.5047
Other information
Title:

Circular RNAs in peripheral blood mononuclear cells from ankylosing spondylitis.

Journal: Chinese medical journal
Published: 2021
PubMed ID: 34670246
Study type:

combined biological and clinical study
Data availability: -
Code availability: -