circRNA basic information
circBase ID: hsa_circ_0001681
Name: hsa_circ_RAPGEF5
Synonym: -
Host Gene: RAPGEF5
Genomic location(hg19): chr7:22330793-22357656:-
Genomic location(hg38): chr7:22291174-22318037:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid cancer
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tissues; adjacent noncancerous thyroid tissues
Cell lines:

Nthy-ori 3-1; BCPAP; KTC-1; K1; HEK293; HEK293T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: FGFR1
Associated microRNA: miR-198
Biological function: promotes cell proliferation, migration, and invasion; promotes tumor growth
Molecular mechanism: ceRNA/miRNA sponge: circRAPGEF5 sponges miR-198 to relieve repression of FGFR1
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

potential biomarker and therapeutic target for the management of PTC; could be a promising prognostic biomarker in PTC
Description:

circRAPGEF5 is up-regulated in papillary thyroid cancer and promotes proliferation, migration/invasion and xenograft tumor growth. Mechanistically, it acts as a miRNA sponge for miR-198, thereby increasing FGFR1 expression via a circRAPGEF5/miR-198/FGFR1 ceRNA axis.
Confidence score:

0.6829
Other information
Title:

circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1.

Journal: Molecular therapy. Nucleic acids
Published: 2019
PubMed ID: 30785065
Study type:

combined biological and clinical study
Data availability: Supplemental Information includes one figure and can be found with this article online at https://doi.org/10.1016/j.omtn.2019.01.003.
Code availability: -