circRNA basic information
circBase ID: hsa_circ_0020417
Name: hsa_circ_DOCK1
Synonym: -
Host Gene: DOCK1
Genomic location(hg19): chr10:128768965-129245809:+
Genomic location(hg38): chr10:126970701-127447545:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005010
MONDO name: coronary artery disorder
Disease details: coronary artery disease / CAD
Disease DO ID:
 3393
Disease MeSH ID:
 D003324
Disease NCIt ID:
 C26732
Disease ICD11 ID:
 1059873720
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

Peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MKRN1, UBE2H, UBE2W, UBE2D1, UBE2F, BE2J1, ZNRF1, SIAH2
Associated microRNA: -
Biological function: unknown
Molecular mechanism: Predicted to act as miRNA sponges in a circRNA-miRNA-mRNA (ceRNA) regulatory network to regulate hub genes, potentially involving ubiquitin-mediated proteolysis.
Biological pathway or process:

ceRNA regulation (other); ubiquitination (other); other pathway/process (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0020417 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.
Confidence score:

0.1768
Other information
Title:

Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.

Journal: Cardiology research and practice
Published: 2022
PubMed ID: 35223093
Study type:

bioinformatics study
Data availability: GSE115733; GSE59421; GSE97320
Code availability: -