circRNA basic information
circBase ID: hsa_circ_0001445
Name: hsa_circ_TFRC
Synonym: -
Host Gene: TFRC
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; paired adjacent normal bladder tissues; xenograft tumor tissues
Cell lines:

EJ; T24; 5637; UMUC3; BIU87; J82; SW780; HCV29
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TFRC
Associated microRNA: miR-107
Biological function: promotes bladder cancer cell proliferation and invasion, promotes EMT, and promotes tumor growth in vivo
Molecular mechanism: cTFRC acts as a ceRNA/miRNA sponge by binding miR-107, thereby relieving miR-107-mediated repression of TFRC and promoting EMT and progression
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); EMT (promotes); metastasis (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; Transfection; RNA Pull-Down; Luciferase Reporter Assay; Western Blot; Transwell Assay; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

cTFRC expression correlated with tumor grade and poor overall survival; may be a potential marker of BC diagnosis or progression
Description:

cTFRC is up-regulated in bladder cancer and is associated with higher grade, metastasis-related features, and poorer overall survival. Functionally, cTFRC promotes proliferation, invasion, EMT, and xenograft tumor growth by acting as a ceRNA that sponges miR-107, thereby de-repressing TFRC.
Confidence score:

0.8071
Other information
Title:

Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression.

Journal: Molecular cancer
Published: 2019
PubMed ID: 30782157
Study type:

combined biological and clinical study
Data availability: TCGA
Code availability: -