| Expression pattern: |
UP |
| Associated gene: |
FOXK1 |
| Associated microRNA: |
miR-3186-3p |
| Biological function: |
Promotes proliferation and glycolysis; inhibits autophagy and apoptosis; promotes tumor growth in vivo in NSCLC. |
| Molecular mechanism: |
Acts as a ceRNA sponging miR-3186-3p to augment FOXK1 expression; effects can be rescued by miR-3186-3p inhibitor or FOXK1 knockdown. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); autophagy (inhibits); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circEHD2 is up-regulated in NSCLC tissues/cells and acts oncogenically by promoting proliferation and glycolysis while inhibiting apoptosis and autophagy. Mechanistically, it sponges miR-3186-3p to increase FOXK1, and knockdown of circEHD2 suppresses xenograft tumor growth. |
| Confidence score: |
0.6278 |