| Expression pattern: |
UP |
| Associated gene: |
RAB21 |
| Associated microRNA: |
miR-326 |
| Biological function: |
promotes proliferation, migration, invasion, EMT, and tumor growth in HCC |
| Molecular mechanism: |
ceRNA mechanism: circ_0008043 sponges miR-326 to release RAB21, promoting malignant phenotypes |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; ROC Analysis |
| Clinical significance: |
Diagnostic value (ROC AUC=0.9589) and association with AFP, tumor size, differentiation, and distant metastasis |
| Description: |
circ_0008043 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and EMT by sponging miR-326 to increase RAB21, and its knockdown suppresses xenograft tumor growth. It also shows diagnostic potential by ROC analysis and correlates with aggressive clinicopathologic features. |
| Confidence score: |
0.8315 |