| Expression pattern: |
DN |
| Associated gene: |
PTEN, p53 |
| Associated microRNA: |
miR-130a, miR-107 |
| Biological function: |
inhibits gastric cancer cell proliferation, induces cell cycle arrest, and promotes apoptosis; suppresses tumor growth in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism: circ-ZFR sponges miR-130a and miR-107 to modulate PTEN expression; associated with p53 signaling pathway involvement |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); cell cycle (inhibits); p53 signaling (other); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
circ-ZFR is down-regulated in gastric cancer tissues and cell lines. Functionally, circ-ZFR acts as a tumor suppressor by inhibiting proliferation and cell cycle progression and promoting apoptosis, largely by sponging miR-130a and miR-107 to relieve repression of PTEN, and it suppresses tumor growth in a nude-mouse xenograft model. |
| Confidence score: |
0.7884 |