circRNA basic information
circBase ID: hsa_circ_0029426
Name: hsa_circ_RAN
Synonym: -
Host Gene: RAN
Genomic location(hg19): chr12:131357380-131357465:+
Genomic location(hg38): chr12:130872835-130872920:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma / LUAD
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor tissues; adjacent normal tissue samples; serum
Cell lines:

PC9; H460; A549; H1299; BEAS-2B
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: KRAS, ETS1, KARS
Associated microRNA: miR-7-5p, miR-377-3p, miR-320a, miR-134-5p, miR-382-5p, miR-181a-5p, miR-876-5p, miR-183-5p, miR-197-3p, miR-384
Biological function: unknown
Molecular mechanism: May bind miRNAs to regulate downstream genes in a circRNA-miRNA-mRNA (ceRNA) network.
Biological pathway or process:

ceRNA regulation (other); Ras signaling (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; divergent primers PCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

High levels of circ_0029426 are associated with poor OS in LUAD patients; ROC AUC in tissue 0.758 and in serum 0.841.
Description:

circ_0029426 is down-regulated in LUAD tissues, serum, and lung cancer cell lines, is mainly localized in the cytoplasm, and is proposed to act within a predicted ceRNA network by binding multiple miRNAs and regulating hub genes such as KRAS/ETS1 (and KARS in the PPI analysis). Despite being down-regulated, high circ_0029426 levels are associated with poor overall survival, and it shows diagnostic value by ROC analysis.
Confidence score:

0.7329
Other information
Title:

Circular RNA-microRNA-mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma.

Journal: Bioengineered
Published: 2022
PubMed ID: 35212617
Study type:

combined biological and clinical study
Data availability: GSE158695; GSE101684; GSE112214; Supplemental data for this article can be accessed here.
Code availability: -