| Expression pattern: |
DN |
| Associated gene: |
TMEFF2 |
| Associated microRNA: |
hsa-miR-198, hsa-miR-323a-3p, hsa-miR-338-3p, hsa-miR-548c-3p, hsa-miR-609 |
| Biological function: |
Potential biomarker for GC screening; may function as an inhibitor of miRNAs in a GC risk-related ceRNA network. |
| Molecular mechanism: |
Predicted ceRNA mechanism in which hsa_circ_0005927 may bind miRNAs and regulate downstream mRNAs such as TMEFF2. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Could be a more authentic biomarker for GC screening. |
| Description: |
hsa_circ_0005927 was identified as a down-regulated circRNA in gastric cancer by integrated microarray MetaDE analysis and was validated by qRT-PCR in clinical tissues. The study proposes that it may act through a circRNA-miRNA-mRNA ceRNA network, potentially binding multiple miRNAs and regulating downstream targets such as TMEFF2, and it may serve as a biomarker for GC screening. |
| Confidence score: |
0.4032 |