circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3 / circRNA HIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; tumor-adjacent tissues; xenograft tumors
Cell lines:

HepG2; SMMC-7721; Bel-7402; Huh-7; HL7702
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: PDK2
Associated microRNA: miR-124, miR-506
Biological function: accelerates proliferation and invasion; promotes tumor formation/growth in vivo
Molecular mechanism: circHIPK3 acts as a miRNA sponge for miR-124 and miR-506, thereby relieving repression of PDK2 (ceRNA regulatory loop).
Biological pathway or process:

proliferation (promotes); invasion (promotes); tumorigenesis (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Transfection; CCK8; EdU Staining; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

Upregulated in HCC patients and associated with tumor size, lymph node metastasis and TNM stage.
Description:

circHIPK3 is up-regulated in HCC tissues and cell lines and promotes HCC cell proliferation and invasion as well as xenograft tumor growth. It functions as a ceRNA by sponging miR-124 and miR-506, thereby upregulating the downstream target gene PDK2.
Confidence score:

0.6966
Other information
Title:

The novel circular RNA HIPK3 accelerates the proliferation and invasion of hepatocellular carcinoma cells by sponging the micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis.

Journal: Bioengineered
Published: 2022
PubMed ID: 35212603
Study type:

combined biological and clinical study
Data availability: The data and material are available from the corresponding author upon reasonable request.
Code availability: -