| Expression pattern: |
DN |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-296-5p |
| Biological function: |
Suppresses gastric cancer cell proliferation, migration, invasion and metastasis; inhibits tumor growth in vivo. |
| Molecular mechanism: |
Acts as a competitive endogenous RNA (ceRNA) to sponge miR-296-5p, thereby increasing PTEN expression. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; RNA Pull-Down; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Lower circPSMC3 expression in GC patients was correlated with higher TNM stage and shorter overall survival; potential circulating biomarker for detection of GC; ROC AUC 0.9326 for distinguishing GC plasmas and normal ones. |
| Description: |
circPSMC3 is down-regulated in gastric cancer tissues, plasma, and cell lines and functions as a tumor suppressor. It sponges miR-296-5p to relieve repression of PTEN, thereby inhibiting proliferation, migration/invasion, and metastasis, and shows diagnostic/prognostic potential as a circulating biomarker. |
| Confidence score: |
0.8498 |