| Expression pattern: |
UP |
| Associated gene: |
MACC1 |
| Associated microRNA: |
miR-186-5p |
| Biological function: |
promotes osteosarcoma cell proliferation, migration, and invasion |
| Molecular mechanism: |
ceRNA sponging miR-186-5p to upregulate MACC1 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; Bioinformatics Analysis; Survival Analysis; Luciferase Reporter Assay |
| Clinical significance: |
High circ_0001174 expression was closely associated with shorter disease-free survival (DFS). |
| Description: |
circ_0001174 is up-regulated in osteosarcoma tissues and cell lines and promotes OS cell proliferation, migration, and invasion. It acts as a ceRNA by sponging miR-186-5p, thereby increasing MACC1 expression and associating with shorter disease-free survival. |
| Confidence score: |
0.7369 |