| Expression pattern: |
UP |
| Associated gene: |
TWIST1 |
| Associated microRNA: |
hsa-miR-566 |
| Biological function: |
Promotes proliferation and invasion of lung cancer cells; knockdown inhibits proliferation and invasion. |
| Molecular mechanism: |
hsa_circ_0014130 may act as a miRNA sponge targeting hsa-miR-566, thereby enhancing TWIST1 expression and affecting the TGF-beta-related epithelial-mesenchymal transition signaling pathway. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); EMT (promotes); TGF-beta/SMAD (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; MTT; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
Potential lung cancer treatment target; SB-431542 is suggested as a potential small molecule inhibitor for patients with high hsa_circ_0014130 expression. |
| Description: |
This study found that hsa_circ_0014130 is up-regulated in several lung cancer cell lines and acts as an oncogenic circRNA in lung cancer cells. It promotes proliferation and invasion, likely through targeting hsa-miR-566 and enhancing TWIST1 expression in a TGF-beta/EMT-related context, and it is proposed as a potential therapeutic target. |
| Confidence score: |
0.4546 |