circRNA basic information
circBase ID: -
Name: hsa_circ_CDR1AS
Synonym: circ_463 / ciRS-7
Host Gene: LINC00632
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007959
MONDO name: medulloblastoma
Disease details: medulloblastoma / MB
Disease DO ID:
 0050902, 0060104
Disease MeSH ID:
 D008527
Disease NCIt ID:
 C3222
Disease ICD11 ID:
 290815825
Disease OMIM ID:
 155255
Species: Human
Species details: Homo sapiens
Tissue specimen:

cerebrospinal fluid / CSF
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-7
Biological function: potential oncogenic role in medulloblastoma CSF context
Molecular mechanism: miR-7 sponge (ceRNA-like interaction)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation
Clinical significance:

candidate biomarker in CSF to discriminate medulloblastoma from normal
Description:

circ_463 (ciRS-7/CDR1as) is significantly up-regulated in medulloblastoma patient CSF and was qRT-PCR validated as the most upregulated/abundant circRNA among the DE circRNAs. It may act as a miR-7 sponge and is proposed as a candidate CSF biomarker and potential oncogenic circRNA in this context.
Confidence score:

0.3588
Other information
Title:

Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs.

Journal: Acta neuropathologica communications
Published: 2022
PubMed ID: 35209946
Study type:

combined biological and clinical study
Data availability: GSE189919
Code availability: -