| Expression pattern: |
UP |
| Associated gene: |
PTGS2 |
| Associated microRNA: |
hsa-miR-545 |
| Biological function: |
Acts as a ceRNA in AMI network; proposed to restrain miR-545 function to affect PTGS2 reduction. |
| Molecular mechanism: |
ceRNA mechanism via miR-545 to regulate PTGS2. |
| Biological pathway or process: |
ceRNA regulation (other); inflammation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; Bioinformatics Analysis; Transfection |
| Clinical significance: |
- |
| Description: |
hsa_circ_0030569 is up-regulated in AMI and was validated by qRT-PCR. It is proposed to participate in a ceRNA axis by binding hsa-miR-545, thereby influencing PTGS2 expression and inflammation-related MI injury. |
| Confidence score: |
0.5922 |