circRNA basic information
circBase ID: -
Name: hsa_circ_HIPK3
Synonym: circHIPK3 / circRNA homeodomain-interacting protein kinase 3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004994
MONDO name: cardiomyopathy
Disease details: diabetic cardiomyopathy
Disease DO ID:
 0050700
Disease MeSH ID:
 D009202
Disease NCIt ID:
 C34830
Disease ICD11 ID:
 282225286
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

AC16
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: -
Biological function: protects cardiomyocytes from high glucose-induced apoptosis
Molecular mechanism: circHIPK3 negatively regulates PTEN expression (PTEN mRNA and protein), potentially by affecting PTEN transcription or PTEN mRNA stability
Biological pathway or process:

apoptosis (inhibits); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

circHIPK3 is down-regulated in diabetic cardiomyopathy (and also decreased in diabetes). In AC16 cardiomyocytes under high glucose, circHIPK3 overexpression reduces PTEN mRNA/protein and suppresses high glucose-induced apoptosis, suggesting a protective role via negative regulation of PTEN.
Confidence score:

0.5546
Other information
Title:

Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis.

Journal: Bioengineered
Published: 2022
PubMed ID: 35200097
Study type:

combined biological and clinical study
Data availability: The analyzed data sets generated during the study are available from the corresponding author on reasonable request.
Code availability: -