circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: CircRNA ZFR
Host Gene: ZFR
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC species; paracancerous species
Cell lines:

Bel-7402; HepG2; MH-CC88H; SMMC-7221; Huh7; Hep3B; LO2
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MAP2K1
Associated microRNA: -
Biological function: Promotes proliferative ability of HCC cells; higher expression is linked to more advanced tumor grading.
Molecular mechanism: CircRNA ZFR promotes HCC cell proliferation by upregulating MAP2K1; MAP2K1 can reverse the effects of circRNA ZFR knockdown.
Biological pathway or process:

proliferation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Luciferase Reporter Assay; Bioinformatics Analysis
Clinical significance:

Higher level of circRNA ZFR predicted more advanced tumor grading of HCC.
Description:

CircRNA ZFR is upregulated in HCC tissues and cell lines, and its higher expression is associated with more advanced tumor grading. Functionally, circRNA ZFR promotes HCC cell viability and colony formation, at least partly through upregulating MAP2K1.
Confidence score:

0.6369
Other information
Title:

CircRNA ZFR stimulates the proliferation of hepatocellular carcinoma through upregulating MAP2K1.

Journal: European review for medical and pharmacological sciences
Published: 2020
PubMed ID: 33090396
Study type:

combined biological and clinical study
Data availability: -
Code availability: -