circRNA basic information
circBase ID: hsa_circ_0004093
Name: hsa_circ_MAP7D1
Synonym: circMAP7D1
Host Gene: MAP7D1
Genomic location(hg19): chr1:36636571-36639079:+
Genomic location(hg38): chr1:36170970-36173478:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; para-carcinoma tissues
Cell lines:

AGS; MKN-45; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: NFIB, HER2
Associated microRNA: -
Biological function: Promotes GC cell proliferation and inhibits apoptosis; contributes to tumor progression by stabilizing HER2 mRNA.
Molecular mechanism: NFIB upregulates circMAP7D1; circMAP7D1 interacts with HER2 and increases HER2 mRNA stability.
Biological pathway or process:

proliferation (promotes); apoptosis (inhibits); cell cycle (promotes); mRNA stability (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Actinomycin D / DRB Stability Assay; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry
Clinical significance:

-
Description:

circMAP7D1 is up-regulated in gastric cancer tissues and cells. It promotes GC cell proliferation and cell-cycle progression and inhibits apoptosis. Mechanistically, NFIB upregulates circMAP7D1, which binds HER2 and increases HER2 mRNA stability, contributing to tumor progression.
Confidence score:

0.7592
Other information
Title:

NFIB promotes the progression of gastric cancer by upregulating circMAP7D1 to stabilize HER2 mRNA.

Journal: Molecular medicine reports
Published: 2021
PubMed ID: 33576439
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.
Code availability: -