| Expression pattern: |
DN |
| Associated gene: |
EGFR |
| Associated microRNA: |
hsa-miR-103a-3p |
| Biological function: |
diagnostic biomarker potential for LUAD; associated with EGFR mutation status |
| Molecular mechanism: |
Hypothesized miRNA-binding involvement in EGFR mutation; miRNA targets predicted by bioinformatics (not experimentally validated). |
| Biological pathway or process: |
ceRNA regulation (other); EGFR (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis |
| Clinical significance: |
Part of a two-circRNA plasma diagnostic signature for LUAD (AUC 0.81); high plasma hsa_circ_0086414 expression correlates with EGFR mutations. |
| Description: |
hsa_circ_0086414 is down-regulated in LUAD plasma and LUAD cell lines and, together with hsa_circ_0005962, forms a plasma circRNA diagnostic signature for LUAD. Higher plasma hsa_circ_0086414 levels are associated with EGFR mutation status, and the study hypothesizes a miRNA-binding mechanism based on bioinformatic prediction. |
| Confidence score: |
0.5047 |