| Expression pattern: |
UP |
| Associated gene: |
Akt, mTOR, Ago2 |
| Associated microRNA: |
miR-147a |
| Biological function: |
promotes NPC proliferation and cisplatin (DDP) resistance; inhibits apoptosis; promotes in vivo tumor growth |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-147a, thereby activating Akt/mTOR signaling and increasing cisplatin resistance. |
| Biological pathway or process: |
PI3K/AKT/mTOR (promotes); proliferation (promotes); apoptosis (inhibits); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
circSETD3 was related to DDP resistance in NPC and its high expression was associated with TNM stage and metastasis. |
| Description: |
circSETD3 is up-regulated in nasopharyngeal carcinoma and further elevated in cisplatin-resistant settings. It promotes proliferation, inhibits apoptosis, and enhances cisplatin resistance by sponging miR-147a and activating Akt/mTOR signaling, and its knockdown suppresses xenograft tumor growth and improves cisplatin response. |
| Confidence score: |
0.7548 |